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Polystyrene nanoplastics and cadmium co-exposure aggravated cardiomyocyte damage in mice by regulating PANoptosis pathway.
Ye, Jiali; Qiu, Wenyue; Pang, Xiaoyue; Su, Yiman; Zhang, Xinting; Huang, Jianjia; Xie, Haoming; Liao, Jianzhao; Tang, Zhaoxin; Chen, Zefeng; Li, Fei; Xiong, Zhaojun; Su, Rongsheng.
Afiliación
  • Ye J; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Qiu W; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Pang X; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Su Y; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Zhang X; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Huang J; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Xie H; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Liao J; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Tang Z; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Chen Z; Department of Cardiovascular Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou City, Guangdong Province, China.
  • Li F; Department of Cardiovascular Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou City, Guangdong Province, China.
  • Xiong Z; Department of Cardiovascular Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou City, Guangdong Province, China.
  • Su R; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. Electronic address: srsh168@163.com.
Environ Pollut ; 347: 123713, 2024 Apr 15.
Article en En | MEDLINE | ID: mdl-38462200
ABSTRACT
Micro/nanoplastics (M/NPs) are the novel contaminants ubiquitous in the environment. Cadmium (Cd), a kind of heavy metal pollutant widely distributed, could potentially co-exist with PS-NPs in the environment. However, their combined effects on cardiomyocyte and its molecular mechanism in mammals remained ambiguous. Here, we examined whether PANoptosis, an emerging and complicated kind of programmed cell death, was involved in PS-NPs and Cd co-exposure-elicited cardiac injury. In this study, 60 male mice were orally subjected to environmentally relevant concentrations of PS-NPs (1 mg/kg) and/or CdCl2 (1.5 mg/kg) for 35 days. As we speculated, PS-NPs and Cd co-exposure affected the expression of pyroptosis(Caspase-1, Cleaved-Caspase-1, GSDMD, N-GSDMD, AIM2, Pyrin, NLRP3, IL-18, IL-1ß)-, apoptosis(Caspase-3, Cleaved-Caspase-3, Caspase-8, Cleaved-Caspase-8, Caspase-7, BAX)- and necroptosis (t-RIPK3, p-RIPK3, t-RIPK1, p-RIPK1, t-MLKL, p-MLKL, ZBP1)-related genes and protein, resulting in growth restriction and damaged myocardial microstructure in mice. Notably, the combined effects on Cd and PS-NPs even predominantly aggravated the toxic damage. Intriguingly, we fortuitously discovered PS-NPs and/or Cd exposure facilitated linear ubiquitination of certain proteins in mice myocardium. In summation, this study shed light toward the effects of Cd and PS-NPs on cardiotoxicity, advanced the understanding of myocardial PANoptosis and provided a scientific foundation for further exploration of the combined toxicological effects of PS-NPs and heavy metals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Miocitos Cardíacos Límite: Animals Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Miocitos Cardíacos Límite: Animals Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China