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Fluoride-related changes in the fetal cord blood proteome; a pilot study.
Tuomivaara, Sami T; Goin, Dana E; Fisher, Susan J; Hall, Steven C; Mattis, Aras N; Den Besten, Pamela K.
Afiliación
  • Tuomivaara ST; University of California, San Francisco San Francisco.
  • Goin DE; University of California, San Francisco San Francisco.
  • Fisher SJ; University of California, San Francisco San Francisco.
  • Hall SC; University of California, San Francisco San Francisco.
  • Mattis AN; University of California, San Francisco San Francisco.
  • Den Besten PK; University of California, San Francisco San Francisco.
Res Sq ; 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38464284
ABSTRACT

Background:

Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride affects human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in Northern California with either high or low fluoride exposure, as identified by maternal serum fluoride concentrations.

Objective:

To identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women living in Northern California.

Methods:

The proteomes of 19 archived second-trimester cord blood samples representing highest and lowest serum fluoride concentrations from a cohort of 48 women living in Northern California, previously analyzed for serum, urine and amniotic fluoride concentrations, were characterized by mass spectrometry. Proteins highly correlated to maternal serum fluoride concentrations were identified, and further compared in a group of samples from women with the highest serum fluoride to the group with the lowest maternal serum fluoride concentrations.

Results:

Nine cord blood proteins were significantly correlated with maternal serum fluoride concentrations. Six of these proteins, including apolipoprotein B-100, delta homolog 1, coagulation factor X, mimecan, plasma kallikrein, and vasorin, were significantly decreased in the cord blood from women with the highest serum fluoride levels.

Conclusion:

Changes in the relative amounts of second trimester cord blood proteins included proteins associated with the development of the fetal hematopoetic system.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos