Undescribed (2-7')-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production.
Fitoterapia
; 175: 105903, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38479620
ABSTRACT
A phytochemical study of the aerial parts of Piper mutabile C. DC. revealed seven undescribed compounds [two (2-7')-neolignans and five polyoxygenated cyclohexene glycosides] and six known propenylcatechol derivatives. The chemical structures of the isolated compounds were elucidated by extensive HR-ESI-MS and NMR analyses, as well as comparison with the literature. The absolute configurations of the (2-7')-neolignans were confirmed by GIAO 13C NMR calculations with a sorted training set strategy and TD-DFT calculation ECD spectra. The (2-7')-neolignans and polyoxygenated cyclohexene glycosides are unusual in natural sources. Undescribed neolignans 1 and 2 inhibited NO production in RAW 264.7 cells, with respective IC50 values of 14.4 and 9.5 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lignanos
/
Piper
/
Componentes Aéreos de las Plantas
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Ciclohexenos
/
Fitoquímicos
/
Glicósidos
/
Óxido Nítrico
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article