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Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer.
Dickey, Erin M; Bianchi, Anna; Amirian, Haleh; Hosein, Peter J; Faustman, Denise; Brambilla, Roberta; Datta, Jashodeep.
Afiliación
  • Dickey EM; Division of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Bianchi A; Division of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Amirian H; Division of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Hosein PJ; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Faustman D; Sylvester Comprehensive Cancer Center, Miami, FL, USA.
  • Brambilla R; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Datta J; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Oncoimmunology ; 13(1): 2326694, 2024.
Article en En | MEDLINE | ID: mdl-38481728
ABSTRACT
Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction - two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Receptores Tipo II del Factor de Necrosis Tumoral Límite: Humans Idioma: En Revista: Oncoimmunology Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Receptores Tipo II del Factor de Necrosis Tumoral Límite: Humans Idioma: En Revista: Oncoimmunology Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos