Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review.
Pathologica
; 116(1): 62-68, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38482676
ABSTRACT
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers and among these infiltrating lobular carcinomas (ILC) represents only 1-2% of all MBC cases. Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of ILC with only eight cases reported until now in males. Up to 10% of MBC cases have a germline pathogenic variant in a predisposing gene such as BRCA1 and BRCA2 genes. Mutations in PALB2 (partner and localizer of BRCA2) have been reported in men with breast cancer, with a frequency that ranges from 0.8 to 6.4%, but it has never been reported in male ILC. Here, we report a rare and interesting case of an invasive pleomorphic/solid lobular carcinoma, which carries a pathogenic variant in PALB2 gene, and a family history of breast cancer without other well defined risk factors for developing this type of neoplasia. In addition, we review the current literature.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Carcinoma Lobular
/
Neoplasias de la Mama Masculina
Límite:
Humans
/
Male
Idioma:
En
Revista:
Pathologica
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia