Epigenetic regulation of TGF-ß pathway and its role in radiation response.

ABSTRACT

PURPOSE: Transforming growth factor (TGF-ß) plays a dual role in tumor progression as well as a pivotal role in radiation response. TGF-ß-related epigenetic regulations, including DNA methylation, histone modifications (including methylation, acetylation, phosphorylation, ubiquitination), chromatin remodeling and non-coding RNA regulation, have been found to affect the occurrence and development of tumors as well as their radiation response in multiple dimensions. Due to the significance of radiotherapy in tumor treatment and the essential roles of TGF-ß signaling in radiation response, it is important to better understand the role of epigenetic regulation mechanisms mediated by TGF-ß signaling pathways in radiation-induced targeted and non-targeted effects. CONCLUSIONS: By revealing the epigenetic mechanism related to TGF-ß-mediated radiation response, summarizing the existing relevant adjuvant strategies for radiotherapy based on TGF-ß signaling, and discovering potential therapeutic targets, we hope to provide a new perspective for improving clinical treatment.