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Comparison of Outcomes in Patients Requiring Mechanical Circulatory Support Who Received Cangrelor in Addition to Anticoagulation Versus Anticoagulation Alone.
Martin, Trent C; Duewell, Brittney E; Juul, Janelle J; Rinka, Joseph R G; Rein, Lisa; Feih, Joel T.
Afiliación
  • Martin TC; Department of Pharmacy, Froedtert Hospital, Milwaukee, WI. Electronic address: trentmartin@virginia.edu.
  • Duewell BE; Department of Pharmacy, Froedtert Hospital, Milwaukee, WI.
  • Juul JJ; Department of Pharmacy, Froedtert Hospital, Milwaukee, WI.
  • Rinka JRG; Department of Pharmacy, Froedtert Hospital, Milwaukee, WI; School of Pharmacy, Concordia University Wisconsin, Mequon, WI.
  • Rein L; Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
  • Feih JT; Department of Pharmacy, Froedtert Hospital, Milwaukee, WI; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI.
J Cardiothorac Vasc Anesth ; 38(6): 1328-1336, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38521630
ABSTRACT

OBJECTIVES:

To evaluate the safety of cangrelor administered concurrently with heparin or bivalirudin in patients on mechanical circulatory support.

DESIGN:

A single-center, retrospective cohort study of adult patients consecutively admitted between January 2016 and October 2020.

SETTING:

A tertiary medical center.

PARTICIPANTS:

Adult patients admitted to the cardiovascular intensive care unit put on mechanical circulatory support for acute myocardial infarction (AMI) or non-AMI indications. Patients who received cangrelor underwent percutaneous coronary intervention with stenting during the index event or within the last year.

INTERVENTIONS:

None. MEASUREMENTS AND MAIN

RESULTS:

The primary outcome was the incidence of major bleeding, defined by the Extracorporeal Life Support Organization criteria, in patients with mechanical circulatory support receiving cangrelor plus anticoagulation with heparin or bivalirudin with or without aspirin versus patients who did not receive cangrelor. Sixty-eight patients were included in the study. Twenty-nine patients received cangrelor, and 39 did not. Cangrelor was not associated with an increase in major bleeding; however, the CI was wide (adjusted hazard ratio 1.93, 95% CI 0.61-6.11; p = 0.262).

CONCLUSIONS:

Patients receiving cangrelor did not appear to be at higher risk of major bleeding compared to patients not receiving cangrelor. Larger trials should be conducted to better evaluate the safety of cangrelor in patients with mechanical circulatory support.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Monofosfato / Anticoagulantes Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiothorac Vasc Anesth Asunto de la revista: ANESTESIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Monofosfato / Anticoagulantes Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiothorac Vasc Anesth Asunto de la revista: ANESTESIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article