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Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation.
Vogel, Sebastian; Kamimura, Sayuri; Smith, Meghann L; Almeida, Luis E F; Cui, Xizhong; Combs, Christian A; Quezado, Zenaide M N.
Afiliación
  • Vogel S; Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
  • Kamimura S; Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
  • Smith ML; Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
  • Almeida LEF; Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
  • Cui X; Critical Care Medicine Department, National Institutes of Health Clinical Center, USA.
  • Combs CA; Light Microscopy Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Quezado ZMN; Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA. Electronic address: zquezado@cc.nih.gov.
Thromb Res ; 237: 18-22, 2024 May.
Article en En | MEDLINE | ID: mdl-38547689
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Agregación Plaquetaria / Inflamasomas / Quinasa Syk / Proteína con Dominio Pirina 3 de la Familia NLR / Anemia de Células Falciformes Límite: Animals Idioma: En Revista: Thromb Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Agregación Plaquetaria / Inflamasomas / Quinasa Syk / Proteína con Dominio Pirina 3 de la Familia NLR / Anemia de Células Falciformes Límite: Animals Idioma: En Revista: Thromb Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos