NLRP3 inflammasome signalling in Alzheimer's disease.
Neuropharmacology
; 252: 109941, 2024 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-38565393
ABSTRACT
Every year, 10 million people develop dementia, the most common of which is Alzheimer's disease (AD). To date, there is no way to prevent cognitive decline and therapies are limited. This review provides a neuroimmunological perspective on the progression of AD, and discusses the immune-targeted therapies that are in preclinical and clinical trials that may impact the development of this disease. Specifically, we look to the role of the NLRP3 inflammasome, its triggers in the brain and how its activation can contribute to the progression of dementia. We summarise the range of inhibitors targeting the NLRP3 inflammasome and its downstream pathways that are under investigation, and discuss future therapeutic perspectives for this devastating condition.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Inflamasomas
/
Enfermedad de Alzheimer
/
Proteína con Dominio Pirina 3 de la Familia NLR
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropharmacology
Año:
2024
Tipo del documento:
Article