Your browser doesn't support javascript.
loading
Prognostic value of preoperative diffusion restriction in glioblastoma.
Labbène, Emna; Mahmoud, Maha; Marrakchi-Kacem, Linda; Ben Hamouda, Mohamed.
Afiliación
  • Labbène E; Department of radiology, MT Kassab institute of orthopaedics, Tunis, Tunisia.
  • Mahmoud M; Faculty of medicine of Tunis, Tunis-El Manar University, Tunis, Tunisia.
  • Marrakchi-Kacem L; Faculty of medicine of Tunis, Tunis-El Manar University, Tunis, Tunisia.
  • Ben Hamouda M; Department of neuroradiology, National institute of neurology Mongi-Ben Hamida, Tunis, Tunisia.
Tunis Med ; 102(2): 94-99, 2024 Feb 05.
Article en En | MEDLINE | ID: mdl-38567475
ABSTRACT

INTRODUCTION:

Although glioblastoma (GBM) has a very poor prognosis, overall survival (OS) in treated patients shows great difference varying from few days to several months. Identifying factors explaining this difference would improve management of patient treatment.

AIM:

To determine the relevance of diffusion restriction in newly diagnosed treatment-naïve GBM patients.

METHODS:

Preoperative magnetic resonance scans of 33 patients with GBM were reviewed. Regions of interest including all the T2 hyperintense lesion were drawn on diffusion weighted B0 images and transferred to the apparent diffusion coefficient (ADC) map. For each patient, a histogram displaying the ADC values within in the regions of interest was generated. Volumetric parameters including tumor regions with restricted diffusion, parameters derived from histogram and mean ADC value of the tumor were calculated. Their relationship with OS was analyzed.

RESULTS:

Patients with mean ADC value < 1415x10-6 mm2/s had a significantly shorter OS (p=0.021). Among volumetric parameters, the percentage of volume within T2 lesion with a normalized ADC value <1.5 times that in white matter was significantly associated with OS (p=0.0045). Patients with a percentage>23.92% had a shorter OS. Among parameters derived from histogram, the 50th percentile showed a trend towards significance for OS (p=0.055) with patients living longer when having higher values of 50th percentile. A difference in OS was observed between patients according to ADC peak of histogram but this difference did not reach statistical significance (p=0.0959).

CONCLUSION:

Diffusion magnetic resonance imaging may provide useful information for predicting GBM prognosis.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma Límite: Humans Idioma: En Revista: Tunis Med Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Túnez

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma Límite: Humans Idioma: En Revista: Tunis Med Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Túnez