Prognostic impact of insomnia in patients receiving trans-catheter aortic valve replacement.
J Cardiol
; 84(2): 113-118, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38580176
ABSTRACT
BACKGROUND:
The presence of insomnia exhibits a profound association with diverse cardiovascular pathologies. However, its prognostic implications in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis remain ambiguous.METHODS:
This retrospective study enrolled patients who underwent TAVR for severe aortic stenosis at a prominent academic center from 2015 to 2022. The impact of insomnia, operationally defined as the prescription of soporific agents, on the two-year composite primary outcome comprising all-cause mortality and hospital readmissions was scrutinized.RESULTS:
A cohort of 345 patients (median age 85â¯years, 99 males) was encompassed in the analysis. All subjects underwent successful TAVR and subsequent discharge. The presence of insomnia (Nâ¯=â¯91) emerged as an independent predictor of the two-year composite endpoint, with an adjusted hazard ratio of 1.66 (95â¯% confidence interval 1.08-2.57, pâ¯=â¯0.022), significantly delineating the two-year cumulative incidence of the primary endpoint (40â¯% versus 30â¯%, pâ¯=â¯0.035).CONCLUSION:
Approximately one-fourth of TAVR candidates manifested symptoms of insomnia, a condition autonomously correlated with heightened mortality and morbidity following the TAVR procedure. The optimal strategy for addressing insomnia in TAVR candidates constitutes a paramount consideration for future interventions.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estenosis de la Válvula Aórtica
/
Reemplazo de la Válvula Aórtica Transcatéter
/
Trastornos del Inicio y del Mantenimiento del Sueño
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Cardiol
Asunto de la revista:
CARDIOLOGIA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos