Complete Blood Count (CBC)-Derived Inflammation Indexes Are Useful in Predicting Metabolic Syndrome in Adults with Severe Obesity.
J Clin Med
; 13(5)2024 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-38592161
ABSTRACT
Background:
Metabolic syndrome (MetS) is a globally increasing pathological condition. Recent research highlighted the utility of complete blood count-derived (CBC) inflammation indexes to predict MetS in adults with obesity.Methods:
This study examined CBC-derived inflammation indexes (NHR, LHR, MHR, PHR, SIRI, AISI, and SII) in 231 adults with severe obesity (88 males, 143 females; age 52.3 [36.4-63.3] years), divided based on the presence (MetS+) or absence (MetS-) of MetS. The relationships between the indexes and the cardiometabolic risk biomarkers HOMA-IR, TG/HDL-C, and non-HDL-C were also evaluated.Results:
Individuals with metabolic syndrome (MetS+) had significantly higher values of MHR, LHR, NHR, PHR, and SIRI than those without (MetS-) (MHR and NHR p < 0.0001; LHR p = 0.001; PHR p = 0.011; SIRI p = 0.021). These values were positively correlated with the degree of MetS severity. Logistic regression (MHR and NHR p = 0.000; LHR p = 0.002; PHR p = 0.022; SIRI p = 0.040) and ROC analysis (MHR AUC = 0.6604; LHR AUC = 0.6343; NHR AUC = 0.6741; PHR AUC = 0.6054; SIRI AUC = 0.5955) confirmed the predictive potential of CBC-derived inflammation indexes for MetS in individuals with severe obesity. CBC-derived inflammation indexes also correlated with HOMA-IR (MHR, LHR, and NHR p < 0.0001; PHR p < 0.001; SIRI p = 0.000) and TG/HDL-C (MHR, LHR, NHR and PHR p < 0.0001; SIRI p = 0.006).Conclusions:
In conclusion, this study validates CBC-derived inflammation indexes for predicting MetS in individuals with severe obesity. The relationships between these indexes and cardiometabolic risk factors can enable clinicians to better grade MetS associated with obesity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Clin Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Suiza