High vs low CPAP strategy with aerosolized calfactant in preterm infants with respiratory distress syndrome.
J Perinatol
; 2024 Apr 09.
Article
en En
| MEDLINE
| ID: mdl-38594414
ABSTRACT
BACKGROUND:
Optimal CPAP strategy to prevent CPAP failure defined as need for endotracheal intubation is unknown.OBJECTIVE:
To evaluate the risk of CPAP failure in infants treated with high vs low CPAP strategy while receiving aerosolized calfactant in the AERO-02 clinical trial and AERO-03 expanded access program.METHODS:
Infants born between 29 0/7 to 36 6/7 weeks were included. Comparisons were made between low and high CPAP groups (Low, 4-7 cm H2O; High, 8-10 cm H2O).RESULTS:
CPAP failure and pneumothorax were not different between the groups. Odds of CPAP failure were not different after adjustment for baseline characteristics (OR = 0.61; 95% CI 0.29, 1.24).CONCLUSION:
We found no difference in CPAP failure among infants who received aerosolized calfactant that were treated with high vs low CPAP strategy. Efficacy of high CPAP strategy with aerosolized surfactant treatment needs to be evaluated in future studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Perinatol
Asunto de la revista:
PERINATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos