Palladium-Catalyzed Iodine Assisted Carbonylation of Indoles with ClCF<sub>2</sub>CO<sub>2</sub>Na and Alcohols.

Cao, Mengting; Zuo, Dandan; Wang, Dan; Li, Yafei; Zhao, Jingjing; Tan, Jiajing; Li, Pan

Palladium-Catalyzed Iodine Assisted Carbonylation of Indoles with ClCF₂CO₂Na and Alcohols.

Cao, Mengting; Zuo, Dandan; Wang, Dan; Li, Yafei; Zhao, Jingjing; Tan, Jiajing; Li, Pan.

Afiliación

Cao M; College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Zuo D; College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Wang D; College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Li Y; College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Zhao J; College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Tan J; Department of Organic Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
Li P; College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.

J Org Chem ; 89(8): 5871-5877, 2024 Apr 19.

Article en En | MEDLINE | ID: mdl-38595315

ABSTRACT

ABSTRACT

A palladium-catalyzed iodine-assisted carbonylation reaction of indoles with readily available ClCF2CO2Na and alcohols has been developed. This protocol provides a practical and efficient approach to highly regioselective indole-3-carboxylates via a preiodination strategy of indoles. Different from classic carbonylation using toxic and difficult-to-handle carbon monoxide, this operationally simple and scalable reaction employed difluorocarbene as the carbonyl surrogate.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article