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Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis.
Torres, Tiago; Sohrt Petersen, Anne; Ivens, Ulla; Bosch Vilaro, Albert; Stinson, John; Carrascosa, José Manuel.
Afiliación
  • Torres T; Centro Hospitalar Universitário de Santo António, University of Porto, Porto, Portugal.
  • Sohrt Petersen A; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark. oypdk@leo-pharma.com.
  • Ivens U; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark.
  • Bosch Vilaro A; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark.
  • Stinson J; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark.
  • Carrascosa JM; Hospital Universitari Germans Trias I Pujol, UAB, IGTP, Badalona, Spain.
Dermatol Ther (Heidelb) ; 14(4): 983-992, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38613642
ABSTRACT

INTRODUCTION:

Tralokinumab and dupilumab are biological agents licensed for the treatment of moderate-to-severe atopic dermatitis (AD) in adult patients who are candidates for systemic treatment. However, no head-to-head studies of their efficacy have been conducted. This study indirectly compared the efficacy of tralokinumab and dupilumab, both in combination with topical corticosteroids (TCS), at week 32.

METHODS:

An unanchored matching-adjusted indirect comparison was conducted using individual patient data (IPD) from the ECZTRA 3 tralokinumab trial and aggregate data from the LIBERTY AD CHRONOS dupilumab trial. IPD were selected by applying inclusion criteria from LIBERTY AD CHRONOS and weighting to match summary baseline characteristics-age, sex, race, body mass index, disease duration, Eczema Area and Severity Index (EASI), Investigator's Global Assessment (IGA), Dermatology Life Quality Index (DLQI) and SCORing Atopic Dermatitis index-of patients treated with dupilumab. Week 32 outcomes of interest were 50%, 75% or 90% improvements in EASI (EASI-50, EASI-75 and EASI-90), IGA scores of 0 or 1 (IGA 0/1), ≥ 4-point improvement in worst daily pruritus numerical rating scale (NRS) score, and mean improvements in DLQI and the Patient Oriented Eczema Measure (POEM).

RESULTS:

After matching, tralokinumab and dupilumab, both in combination with TCS, showed similar efficacy across clinical response endpoints at week 32 (IGA 0/1, tralokinumab 49.9% vs dupilumab 39.3%; EASI-50, 78.9% vs 77.5%; EASI-75, 71.5% vs 71.9%; EASI-90, 53.3% vs 56.2%). The mean change from baseline in DLQI was statistically significantly larger in the matched tralokinumab plus TCS population than in the dupilumab plus TCS arm (- 12.1 vs - 10.4, p = 0.005). Changes in POEM and worst daily pruritus NRS were similar in the two groups.

CONCLUSION:

The results of this analysis demonstrate that, in combination with TCS, tralokinumab and dupilumab have similar efficacy in the treatment of moderate-to-severe AD at 32 weeks of therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Ther (Heidelb) Año: 2024 Tipo del documento: Article País de afiliación: Portugal

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Ther (Heidelb) Año: 2024 Tipo del documento: Article País de afiliación: Portugal
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