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Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity.
Yen, Pham Hai; Tai, Bui Huu; Thuy Hang, Dan Thi; Doan Tung Lam, Le; Dung, Duong Thi; Trang, Do Thi; Thi Hai Yen, Duong; Hoang, Nguyen Huy; Thanh Huong, Phan Thi; Dung, Nguyen Viet; Bang, Ngo Anh; Duy, Nguyen Duc; Van Kiem, Phan.
Afiliación
  • Yen PH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Tai BH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Thuy Hang DT; Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.
  • Doan Tung Lam L; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Dung DT; Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.
  • Trang DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Thi Hai Yen D; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Hoang NH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Thanh Huong PT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Dung NV; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Bang NA; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Duy ND; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam phankiem@yahoo.com.
  • Van Kiem P; Center for High Technology Research and Development, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.
RSC Adv ; 14(17): 12147-12157, 2024 Apr 10.
Article en En | MEDLINE | ID: mdl-38628471
ABSTRACT
In this study, seven new pentacyclic triterpene glycosides, named dendrocinaosides A-G (1-7), and six known ones (8-13) were isolated from the whole plants of Dendrobium officinale. Their structures were determined by analyses of HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-4, 8, and 9 potentially inhibited α-glucosidase and α-amylase activities with the IC50 values ranging from 31.3 ± 2.2 to 42.4 ± 2.5 µM for anti α-glucosidase and from 36.5 ± 1.8 to 56.4 ± 2.0 µM for anti α-amylase activities, respectively, which were lower than that of the positive control, acarbose, showing IC50 values of 47.1 ± 1.4 µM for anti α-glucosidase and 145.7 ± 2.2 µM for anti α-amylase.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido