The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID.
Annu Rev Virol
; 11(1): 327-341, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38631806
ABSTRACT
The effects of SARS-CoV-2 infection on children continue to evolve following the onset of the COVID-19 pandemic. Although life-threatening multisystem inflammatory syndrome in children (MIS-C) has become rare, long-standing symptoms stemming from persistent immune activation beyond the resolution of acute SARS-CoV-2 infection contribute to major health sequelae and continue to pose an economic burden. Shared pathophysiologic mechanisms place MIS-C and long COVID within a vast spectrum of postinfectious conditions characterized by intestinal dysbiosis, increased gut permeability, and varying degrees of immune dysregulation. Insights obtained from MIS-C will help shape our understanding of the more indolent and prevalent postacute sequelae of COVID and ultimately guide efforts to improve diagnosis and management of postinfectious complications of SARS-CoV-2 infection in children.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Respuesta Inflamatoria Sistémica
/
Disbiosis
/
SARS-CoV-2
/
COVID-19
/
Síndrome Post Agudo de COVID-19
Límite:
Child
/
Humans
Idioma:
En
Revista:
Annu Rev Virol
/
Annu. rev. virol. (Online)
/
Annual review of virology (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos