Molecular epidemiology and clinical significance of carbapenemase genes in carbapenem-resistant Acinetobacter baumannii isolates in southern Poland.
Pol Arch Intern Med
; 134(6)2024 Jun 27.
Article
en En
| MEDLINE
| ID: mdl-38656082
ABSTRACT
INTRODUCTION:
A complex interplay between Acinetobacter spp., patients, and the environment has made it increasingly difficult to optimally treat patients infected with Acinetobacter spp., mainly due to rising antimicrobial resistance and challenges with surveillance.OBJECTIVES:
This study evaluated carbapenemresistant A. baumannii (CRAB) isolates to determine their resistance profiles and the presence of specific ßlactamases to inform CRAB surveillance upon hospital admission and regional empiric antibiotic therapies. PATIENTS ANDMETHODS:
The study was conducted at 4 hospitals in southern Poland between June and December 2022. Only health care-associated infections caused by A. baumannii were considered. A total of 82 CRAB isolates were included in the analysis. Species identification was performed by matrixassisted laser desorption / ionization timeofflight mass spectrometry, antimicrobial susceptibility was determined phenotypically, and polymerase chain reactions were carried out to identify the resistance genes.RESULTS:
Depending on the hospital, the incidence of CRAB infections varied from 428.6 to 759.5 per 10 000 admissions in intensive care units (ICUs), and from 0.3 to 21 per 10 000 admissions in nonICUs. CRAB antibiotic susceptibility was the highest for cefiderocol (100%), colistin (96%), tigecycline (77%), gentamicin (51%), and ampicillin / sulbactam (36%). The most prevalent blaOXA genes were blaOXA661 (95%) and blaOXA40 (71%), and additionally the extendedspectrum ßlactamase gene blaTEM1 (41%).CONCLUSION:
An unexpectedly high incidence of CRAB infections occurred in Polish hospitals. There is a need for effective CRAB prevention and control that includes effective hospital screening, national surveillance, and improved treatment options.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Beta-Lactamasas
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Infecciones por Acinetobacter
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Carbapenémicos
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Acinetobacter baumannii
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Pol Arch Intern Med
Año:
2024
Tipo del documento:
Article