Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research.
Clin Chem Lab Med
; 62(10): 1880-1891, 2024 Sep 25.
Article
en En
| MEDLINE
| ID: mdl-38656304
ABSTRACT
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Análisis de la Célula Individual
/
Transcriptoma
Límite:
Humans
Idioma:
En
Revista:
Clin Chem Lab Med
/
Clin. chem. lab. med
/
Clinical chemistry and laboratory medicine
Asunto de la revista:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania