Association between body composition and subsequent cardiovascular diseases among 5-year breast cancer survivors.
Nutr Metab Cardiovasc Dis
; 34(7): 1787-1797, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38658227
ABSTRACT
BACKGROUND AND AIMS:
Cardiovascular disease (CVD) remain one of the leading causes of mortality in breast cancer survivors. This study aimed to investigate the association between body composition and subsequent CVD in breast cancer survivors. METHODS ANDRESULTS:
A retrospective cohort study of more than 70 thousand 5-year breast cancer survivors aged 40 years or older was conducted using data from the National Health Insurance Service of South Korea. Based on the percentage of predicted lean body mass (pLBMP), appendicular skeletal muscle mass (pASMP), and body fat mass (pBFMP), which were calculated using prediction equations with anthropometric data and health habits, groups were equally divided into quartiles. The risk of CVD was evaluated using multivariate Cox proportional hazards regression. Compared to those with the lowest pLBMP and pASMP, those with the highest pLBMP and pASMP had a 38% and 42% lower risk of CVD, respectively. In contrast, those with the highest pBFMP had a 57% higher risk of CVD compared to those with the lowest pBFMP. Each 1 % increase in pLBMP and pASMP was associated with a decreased risk of CVD [pLBMP, adjusted hazard ratio (aHR) 0.96, 95% CI 0.94-0.98, p < 0.05; pASMP, aHR 0.91, 95% CI 0.87-0.95, p < 0.05] while each 1 % increase in pBFMP was associated with the increased risk of CVD (aHR 1.05, 95% CI 1.03-1.07, p < 0.01).CONCLUSION:
In this cohort study, a high pLBMP, a high pASMP, and a low pBFMP were associated with a lower risk of CVD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Composición Corporal
/
Neoplasias de la Mama
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Enfermedades Cardiovasculares
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Adiposidad
/
Supervivientes de Cáncer
Límite:
Adult
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Aged
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Female
/
Humans
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Año:
2024
Tipo del documento:
Article
País de afiliación:
Corea del Sur