The roles of angiotensin-converting enzyme 2 inhibitor, melatonin and its agonist on angiotensin II reactivity in intact and denuded rat aortic rings.
J Recept Signal Transduct Res
; 44(1): 35-40, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38666646
ABSTRACT
BACKGROUND:
The pineal product melatonin (MEL) modulates blood vessels through G protein-coupled receptors (GPCRs) called melatonin type 1 receptor (MT1R) and melatonin type 2 receptor (MT2R), in that order. The renin-angiotensin system (RAS), which breaks down angiotensin II (Ang II) to create Ang 1-7, is thought to be mostly controlled by angiotensin-converting enzyme-2 (ACE2).AIM:
The current work examines the involvement of ACE2 inhibitor, MEL, and ramelteon (RAM) in the vascular response to Ang II activities in the endothelial denuded (E-) and intact (E+) rat isolated thoracic aortic rings.METHOD:
The isometric tension was measured to evaluate the vascular Ang II contractility using dose response curve (DRC).RESULTS:
MEL and RAM caused a rightward shift of Ang II in endothelium E + and endothelium E- aorta.CONCLUSION:
According to the current study, the distribution of MEL receptors and the endothelium's condition are related to the vasomodulatory effect of MEL and ACE2 on Ang II attenuation. These physiological interactions can control vascular tone and increase Ang II reactivity denude endothelial layaer.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Angiotensina II
/
Enzima Convertidora de Angiotensina 2
/
Melatonina
Límite:
Animals
Idioma:
En
Revista:
J Recept Signal Transduct Res
Asunto de la revista:
BIOQUIMICA
/
FISIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irak
Pais de publicación:
Reino Unido