IL-17 Control of Cutaneous Immune Homeostasis.
J Invest Dermatol
; 144(6): 1208-1216, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38678465
ABSTRACT
IL-17 is widely recognized for its roles in host defense and inflammatory disorders. However, it has become clear that IL-17 is also an essential regulator of barrier tissue physiology. Steady-state microbe sensing at the skin surface induces low-level IL-17 expression that enhances epithelial integrity and resists pathogens without causing overt inflammation. Recent reports describe novel protective roles for IL-17 in wound healing and counteracting physiologic stress; however, chronic amplification of these beneficial responses contributes to skin pathologies as diverse as fibrosis, cancer, and autoinflammation. In this paper, we discuss the context-specific roles of IL-17 in skin health and disease and therapeutic opportunities.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Interleucina-17
/
Homeostasis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Invest Dermatol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá