Engineering Cyanine- and Hemicyanine-Based Probes for Optical Imaging of Kidney Diseases.
ChemMedChem
; 19(15): e202400227, 2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-38679574
ABSTRACT
Molecular optical probes play pivotal roles in inâ
vivo imaging of biomarkers associated to kidney diseases. Relying on structural tunability and high fluorescence quantum yields, versatile optical probes have been constructed on cyanine or hemicyanine-based scaffold in recent years. This review summaries the recent progress on the development of optical probes for imaging of kidney diseases, particularly through near-infrared fluorescence, chemiluminescence and photoacoustic imaging modalities. The chemical design and sensing mechanisms are discussed along with applications in the detection of renal cell carcinoma and acute kidney injury. This progress provides insights and directions for the development of next generation kidney-targeted probes and for pushing their further applications in preclinical and clinical research.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbocianinas
/
Imagen Óptica
/
Colorantes Fluorescentes
/
Enfermedades Renales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
ChemMedChem
/
ChemMedChem (Internet)
Asunto de la revista:
FARMACOLOGIA
/
QUIMICA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Alemania