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Sweet, bloody consumption - what we eat and how it affects vascular ageing, the BBB and kidney health in CKD.
Schwarz, Angelina; Hernandez, Leah; Arefin, Samsul; Sartirana, Elisa; Witasp, Anna; Wernerson, Annika; Stenvinkel, Peter; Kublickiene, Karolina.
Afiliación
  • Schwarz A; Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Hernandez L; Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Arefin S; Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Sartirana E; Department of Translational Medicine, Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale, Novara, Italy.
  • Witasp A; Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Wernerson A; Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Stenvinkel P; Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Kublickiene K; Department of Renal Medicine, Karolinska University Hospital, Stockholm, Sweden.
Gut Microbes ; 16(1): 2341449, 2024.
Article en En | MEDLINE | ID: mdl-38686499
ABSTRACT
In today's industrialized society food consumption has changed immensely toward heightened red meat intake and use of artificial sweeteners instead of grains and vegetables or sugar, respectively. These dietary changes affect public health in general through an increased incidence of metabolic diseases like diabetes and obesity, with a further elevated risk for cardiorenal complications. Research shows that high red meat intake and artificial sweeteners ingestion can alter the microbial composition and further intestinal wall barrier permeability allowing increased transmission of uremic toxins like p-cresyl sulfate, indoxyl sulfate, trimethylamine n-oxide and phenylacetylglutamine into the blood stream causing an array of pathophysiological effects especially as a strain on the kidneys, since they are responsible for clearing out the toxins. In this review, we address how the burden of the Western diet affects the gut microbiome in altering the microbial composition and increasing the gut permeability for uremic toxins and the detrimental effects thereof on early vascular aging, the kidney per se and the blood-brain barrier, in addition to the potential implications for dietary changes/interventions to preserve the health issues related to chronic diseases in future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Insuficiencia Renal Crónica / Microbioma Gastrointestinal / Riñón Límite: Animals / Humans Idioma: En Revista: Gut Microbes Año: 2024 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Insuficiencia Renal Crónica / Microbioma Gastrointestinal / Riñón Límite: Animals / Humans Idioma: En Revista: Gut Microbes Año: 2024 Tipo del documento: Article País de afiliación: Suecia