Sweet, bloody consumption - what we eat and how it affects vascular ageing, the BBB and kidney health in CKD.
Gut Microbes
; 16(1): 2341449, 2024.
Article
en En
| MEDLINE
| ID: mdl-38686499
ABSTRACT
In today's industrialized society food consumption has changed immensely toward heightened red meat intake and use of artificial sweeteners instead of grains and vegetables or sugar, respectively. These dietary changes affect public health in general through an increased incidence of metabolic diseases like diabetes and obesity, with a further elevated risk for cardiorenal complications. Research shows that high red meat intake and artificial sweeteners ingestion can alter the microbial composition and further intestinal wall barrier permeability allowing increased transmission of uremic toxins like p-cresyl sulfate, indoxyl sulfate, trimethylamine n-oxide and phenylacetylglutamine into the blood stream causing an array of pathophysiological effects especially as a strain on the kidneys, since they are responsible for clearing out the toxins. In this review, we address how the burden of the Western diet affects the gut microbiome in altering the microbial composition and increasing the gut permeability for uremic toxins and the detrimental effects thereof on early vascular aging, the kidney per se and the blood-brain barrier, in addition to the potential implications for dietary changes/interventions to preserve the health issues related to chronic diseases in future.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Barrera Hematoencefálica
/
Insuficiencia Renal Crónica
/
Microbioma Gastrointestinal
/
Riñón
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Gut Microbes
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suecia