Gram-scale approach for ß-costic acid via allylic oxidation of ß-selinene.

ABSTRACT

ß-Costic acid is a sesquiterpene phytoalexin with acaricidal activity against Varroa destructor and antitrypanosomal activity. A concise and efficient method was developed for the synthesis of ß-costic acid via the allylic oxidation of ß-selinene, a component of celery seed oil.