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Association between plasma metal exposure and health span in very elderly adults: a prospective cohort study with mixture statistical approach.
Ye, Xiaoying; Xu, Tingting; Yang, Le; Hu, Xiangju; Xie, Xiaowei; Lan, Guohui; Lu, Xiaoli; Huang, Zelin; Wang, Tinggui; Wu, Jieyu; Lan, Jieli; Zhang, Qian; Zhan, Zhiying; Guo, Yansong; Xie, Xiaoxu.
Afiliación
  • Ye X; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Xu T; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Yang L; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Hu X; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Xie X; Department for Chronic and Noncommunicable Disease Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
  • Lan G; The First Clinical Medical School, Shanxi Medical University, Taiyuan, China.
  • Lu X; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Huang Z; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Wang T; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Wu J; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Lan J; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Zhang Q; Clinical Research Unit, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.
  • Zhan Z; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Guo Y; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Xie X; Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China. ysguo1234@126.com.
BMC Geriatr ; 24(1): 388, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38693478
ABSTRACT

BACKGROUND:

Metals have been linked to a diverse spectrum of age-related diseases; however, the effects of metal exposure on health span remains largely unknown. This cohort study aims to determine the association between plasma metal and health span in elder adults aged ≥ 90 years.

METHODS:

The plasma concentrations of seven metals were measured at baseline in 300 elder adults. The end of the health span (EHS) was identified as the occurrence of one of eight major morbidities or mortality events. We used Cox regression to assess hazard ratios (HR). The combined effects of multiple metal mixtures were estimated using grouped-weighted quantile sum (GWQS), quantile g-computation (Q-gcomp), and Bayesian kernel machine regression (BKMR) methods.

RESULTS:

The estimated HR for EHS with an inter-quartile range (IQR) increment for selenium (Se) was 0.826 (95% confidence interval [CI] 0.737-0.926); magnesium (Mg), 0.806 (95% CI 0.691-0.941); iron (Fe), 0.756 (95% CI 0.623-0.917), and copper (Cu), 0.856 (95% CI 0.750-0.976). The P for trend of Se, Mg, and Fe were all < 0.05. In the mixture analyses, Q-gcomp showed a negative correlation with EHS (P = 0.904), with the sum of the negative coefficients being -0.211.

CONCLUSION:

Higher plasma Se, Mg, and Fe reduced the risk of premature end of health span, suggesting that essential metal elements played a role in health maintenance in elder adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metales Límite: Aged80 / Female / Humans / Male Idioma: En Revista: BMC Geriatr Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metales Límite: Aged80 / Female / Humans / Male Idioma: En Revista: BMC Geriatr Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido