Prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-neutrophil (PN) index in locally advanced rectal cancer patients: a retrospective cohort study.
Ann Med Surg (Lond)
; 86(5): 2474-2480, 2024 May.
Article
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| MEDLINE
| ID: mdl-38694305
ABSTRACT
Introduction:
In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis.Methods:
Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed.Results:
Post-treatment platelet-to-lymphocyte ratio (PLR) predicted pathological complete response. The neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas the platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, the PN index predicted patients with a higher risk of disease-free survival.Conclusion:
Blood parameters might allow the definition of subgroups of risk beyond TNM for the application of different therapeutic strategies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Ann Med Surg (Lond)
Año:
2024
Tipo del documento:
Article