Pannexins in the musculoskeletal system: new targets for development and disease progression.
Bone Res
; 12(1): 26, 2024 May 06.
Article
en En
| MEDLINE
| ID: mdl-38705887
ABSTRACT
During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication channels. Pannexin (Panx) family and connexin (Cx) family are two important types of channel-forming proteins. Panx family contains three members (Panx1-3) and is expressed widely in bone, cartilage and muscle. Although there is no sequence homology between Panx family and Cx family, they exhibit similar configurations and functions. Similar to Cxs, the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed later. Here, we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis, chondrogenesis, and muscle growth. We also focus on the comparison between Cx and Panx. As a new key target, Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conexinas
/
Progresión de la Enfermedad
/
Sistema Musculoesquelético
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bone Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China