Oral methotrexate in the treatment of HaileyâHailey disease: a case report.
Acta Dermatovenerol Alp Pannonica Adriat
; 33(2): 103-105, 2024 06.
Article
en En
| MEDLINE
| ID: mdl-38708770
ABSTRACT
HaileyâHailey disease is a rare chronic autosomal-dominant blistering disease characterized by erosions, fissures, and vegetations occurring in intertriginous regions. To date, there is no specific treatment and there are no therapeutic guidelines, which makes management of the disease challenging. We present the case of a 43-year-old man unsuccessfully treated for HaileyâHailey disease with topical and systemic corticosteroids, antibiotics, and surgical debridement. At presentation he had erosions, vegetations, and infection in the axillae and groin. We introduced oral methotrexate, 10 mg weekly, and complete remission was achieved in 3 weeks. After 8 weeks, we decided to discontinue methotrexate due to lesion absence. Over 3 years of follow-up, mild flares were effectively managed with topical miconazole or mild steroid creams. We conclude that oral methotrexate is safe and effective for achieving long-term remission in HaileyâHailey disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metotrexato
/
Pénfigo Familiar Benigno
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Acta Dermatovenerol Alp Pannonica Adriat
Asunto de la revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Año:
2024
Tipo del documento:
Article