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Untargeted serum metabolic profiling of diabetes mellitus among Parkinson's disease patients.
Li, Shiwen; Lin, Yuyuan; Jones, Dean; Walker, Douglas I; Duarte Folle, Aline; Del Rosario, Irish; Yu, Yu; Zhang, Keren; Keener, Adrienne M; Bronstein, Jeff; Ritz, Beate; Paul, Kimberly C.
Afiliación
  • Li S; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
  • Lin Y; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
  • Jones D; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, USA.
  • Walker DI; Department of Biochemistry, Emory University School of Medicine, Atlanta, USA.
  • Duarte Folle A; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Del Rosario I; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
  • Yu Y; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
  • Zhang K; Center for Health Policy Research, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
  • Keener AM; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
  • Bronstein J; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.
  • Ritz B; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.
  • Paul KC; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
NPJ Parkinsons Dis ; 10(1): 100, 2024 May 10.
Article en En | MEDLINE | ID: mdl-38730245
ABSTRACT
Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson's disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in serum samples of 636 PD and 253 non-PD participants recruited from Central California. We conducted an initial discovery metabolome-wide association and pathway enrichment analysis. After adjusting for multiple testing, in positive (or negative) ion mode, 30 (25) metabolic features were associated with T2DM in both PD and non-PD participants, 162 (108) only in PD participants, and 32 (7) only in non-PD participants. Pathway enrichment analysis identified 17 enriched pathways associated with T2DM in both the PD and non-PD participants, 26 pathways only in PD participants, and 5 pathways only in non-PD participants. Several amino acid, nucleic acids, and fatty acid metabolisms were associated with T2DM only in the PD patient group suggesting a possible link between PD and T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Parkinsons Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Parkinsons Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos