Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF-κB axis and endoplasmic reticulum stress.
Rev Int Androl
; 22(1): 1-7, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38735871
ABSTRACT
It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2'-deoxyguanosine, superoxide dismutase, catalase, high mobility group box 1 protein, nuclear factor kappa B, tumor necrosis factoralpha, interleukin-6, myeloperoxidase, 78-kDa glucose-regulated protein, activating transcription factor 6, CCAAT-enhancer-binding protein homologous protein and caspase-3 levels were determined using colorimetric methods. The oxidative stress, inflammation, endoplasmic reticulum stress and apoptosis levels increased statistically significantly in the IRI group compared with the sham operated group (p < 0.05). GA application improved these damage significantly (p < 0.05). Moreover, it was found that the results of histological examinations supported the biochemical results to a statistically significant extent. Our findings suggested that GA may be evaluated as a protective agent against testicular IRI.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Torsión del Cordón Espermático
/
Daño por Reperfusión
/
FN-kappa B
/
Estrés Oxidativo
/
Proteína HMGB1
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Estrés del Retículo Endoplásmico
/
Ácido Gálico
Límite:
Animals
Idioma:
En
Revista:
Rev Int Androl
Año:
2024
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Singapur