CardioHotspots: a database of mutational hotspots for cardiac disorders.
Database (Oxford)
; 2024: 0, 2024 May 15.
Article
en En
| MEDLINE
| ID: mdl-38752292
ABSTRACT
Mutational hotspots are DNA regions with an abnormally high frequency of genetic variants. Identifying whether a variant is located in a mutational hotspot is critical for determining the variant's role in disorder predisposition, development, and treatment response. Despite their significance, current databases on mutational hotspots are limited to the oncology domain. However, identifying mutational hotspots is critical for any disorder in which genetics plays a role. This is true for the world's leading cause of death cardiac disorders. In this work, we present CardioHotspots, a literature-based database of manually curated hotspots for cardiac diseases. This is the only database we know of that provides high-quality and easily accessible information about hotspots associated with cardiac disorders. CardioHotspots is publicly accessible via a web-based platform (https//genomics-hub.pros.dsic.upv.es3099/). Database URL https//genomics-hub.pros.dsic.upv.es3099/.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bases de Datos Genéticas
/
Cardiopatías
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Database (Oxford)
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido