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Unraveling Immune Heterogeneity across Pan-Cancer and Deep Insights in Lung Adenocarcinoma based on Alternative Splicing.
Wang, Yuquan; Guo, Erliang; Zou, Min; Lv, Chen; Cui, Yanrui; Zhai, Songmei; Sang, Shaocong; Xiong, Kai; Yang, Xiuqi; Zhuang, Shuping; Gu, Yunyan; Liang, Haihai.
Afiliación
  • Wang Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
  • Guo E; Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
  • Zou M; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Lv C; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Cui Y; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Zhai S; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Sang S; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Xiong K; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Yang X; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Zhuang S; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
  • Gu Y; Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Liang H; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
J Leukoc Biol ; 2024 May 17.
Article en En | MEDLINE | ID: mdl-38758950
ABSTRACT
Alternative splicing (AS) participates in tumor development and tumor microenvironment formation. However, the landscape of immune infiltrating AS events (IIASE) in pan-cancer and mechanisms of AS in lung adenocarcinoma (LUAD) have not been comprehensively characterized. We systematically profiled the IIASE landscape of pan-cancer using data from The Cancer Genome Atlas (TCGA), analyzing both commonalities and specific characteristics among different cancer types. We found that AS events tend to occur specifically in one cancer type rather than in multiple cancer types. AS events were used to classify 512 LUAD samples into two subtypes by unsupervised clustering aberrant splicing subtype (ABS) and immune infiltrating subtype (IIS). The two subtypes showed significant differences in clinicopathology, prognosis, transcriptomics, genomics and immune microenvironment. We constructed a classification signature comprising 10 genes involved in 14 AS events using Logistic regression. The robustness of the signature was validated in three independent datasets using survival analysis. To explore AS mechanisms in LUAD, we constructed subtype-specific co-expression networks using Pearson correlation analysis. AS event of AKT3 regulated by splicing factor ENOX1 was associated with poor prognosis in LUAD. Overall, we outline AS events associated with immune infiltration in pan-cancer and this study provides insights into AS mechanisms in LUAD patient classification.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Leukoc Biol Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Leukoc Biol Año: 2024 Tipo del documento: Article País de afiliación: China