Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1.
Cell Chem Biol
; 31(5): 833-834, 2024 May 16.
Article
en En
| MEDLINE
| ID: mdl-38759616
ABSTRACT
Despite the immense clinical success of the antibody therapeutics that neutralize programmed death receptor ligand 1 (PD-L1) and thus resurrect T cell antitumor activity, the patient response rates remain low. In this issue of Cell Chemical Biology, Ludwig et al.1 reveal novel topologies of multiparatopic antibodies that mediate potent PD-L1 downregulation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígeno B7-H1
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Chem Biol
Año:
2024
Tipo del documento:
Article