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The therapeutic effects of traditional Chinese medicine on insulin resistance in obese mice by modulating intestinal functions.
Ma, Lirong; Bai, Yongquan; Liu, Jun; Gong, Kaimin; He, Qirui; Zhao, Jintao; Suo, Yina; Wang, Wenwen; Chen, Guo; Lu, Zifan.
Afiliación
  • Ma L; Yinchuan Traditional Chinese Medicine Hospital, 750001, Ningxia, China.
  • Bai Y; Department of Bio-pharmacy, Fourth Military Medical University, Xi'an, China.
  • Liu J; Yinchuan Traditional Chinese Medicine Hospital, 750001, Ningxia, China.
  • Gong K; Yinchuan Traditional Chinese Medicine Hospital, 750001, Ningxia, China.
  • He Q; Yinchuan Traditional Chinese Medicine Hospital, 750001, Ningxia, China.
  • Zhao J; Yinchuan Traditional Chinese Medicine Hospital, 750001, Ningxia, China.
  • Suo Y; Yinchuan Traditional Chinese Medicine Hospital, 750001, Ningxia, China.
  • Wang W; Department of Bio-pharmacy, Fourth Military Medical University, Xi'an, China.
  • Chen G; Translational Medicine Center of Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
  • Lu Z; Department of Bio-pharmacy, Fourth Military Medical University, Xi'an, China.
Heliyon ; 10(9): e30379, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38765147
ABSTRACT

Introduction:

Obesity, mainly caused by excessive accumulation of visceral fat, excessive fat metabolism will cause hormone secretion imbalance and inflammation and other diseases. is extremely detrimental to human health. Although many treatments are available for obesity, most treatments fail to exert a radical effect or are associated with several side effects. Traditional Chinese medicine (TCM) for regulating the intestinal flora, lipid content and inflammation is considered effective. Based on previous studies, Artemisia capillaris, Astragalus propinquus, Phellodendron amurense, Salvia miltiorrhiza, Poria cocos, and Anemarrhena asphodeloides were selected to prepare an innovative herbal formula.

Methods:

TCM was characterized by UHPLC-Q-Orbitrap-MS. The anti-inflammatory and lipid-lowering effects of the TCM formula prepared were evaluated in a high-fat diet-fed obese mouse model. The effects of the TCM formula on the intestinal flora were also investigated.

Results:

Weights and insulin resistance, as well as inflammation, decreased in the mice after treatment. At the same time, lipid metabolism increased after the mice were gavaged with the TCM formula for 2 weeks. The intestinal motility of the drug administration group was enhanced, with partial restoration of the intestinal flora.

Conclusion:

In summary, our innovative Chinese herbal formula significantly reduced weight, reduced intestinal inflammation, improved intestinal motility, and improved lipid metabolism in obese mice. Furthermore, the innovative formula effectively prevented relevant obesity-induced metastatic diseases in the mice.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido