LncRNA TINCR: an irreplaceable biological target in human malignancies.
Curr Med Chem
; 2024 May 22.
Article
en En
| MEDLINE
| ID: mdl-38779727
ABSTRACT
BACKGROUND:
Currently, malignant tumors of the digestive system tend to affect younger people, which has brought a catastrophic burden to people around the world. lncRNA has gained considerable attention because of its importance in the early diagnosis and treatment of tumors. In addition, since terminal differentiation-induced ncRNA ( abbreviated as TINCR )was reported in a Nature article, it has received focus on targeted therapy of tumors, especially in digestive system malignant tumors. This review aims to reveal and summarize its important molecular mechanisms in digestive system malignancies.METHOD:
In this review, relevant research involving the relationship between TINCR and digestive system malignancies are collected through systematic retrieval of PubMed.RESULTS:
TINCR is expressed bidirectionally in malignant tumors of the digestive system. TINCR functions primarily as a ceRNA in digestive system tumors, and TINCR also functions at the transcriptional level.CONCLUSION:
lncRNA TINCR has the potential to become a novel biomolecular marker of the digestive system.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Curr Med Chem
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Emiratos Árabes Unidos