A recombinant multi-epitope trivalent vaccine for foot-and-mouth disease virus serotype O in pigs.
Virology
; 596: 110103, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38781710
ABSTRACT
In order to develop a safe and effective broad-spectrum vaccine for foot-and-mouth disease (FMDV), here, we developed a recombinant FMD multiple-epitope trivalent vaccine based on three distinct topotypes of FMDV. Potency of the vaccine was evaluated by immune efficacy in pigs. The results showed that the vaccine with no less than 25 µg of antigen elicited FMDV serotype O specific antibodies and neutralization antibodies by primary-booster regime, and offered immune protection to pigs. More importantly, the vaccine elicited not only the same level of neutralization antibodies against the three distinct topotypes of FMDV, but also provided complete protection in pigs from the three corresponding virus challenge. None of the fully protected pigs were able to generate anti-3ABC antibodies throughout the experiment, which implied the vaccine can offer sterilizing immunity. The vaccine elicited lasting-long high-level antibodies and effectively protected pigs from virulent challenge within six months of immunization. Therefore, we consider that this vaccine may be used in the future for the prevention and control of FMD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de los Porcinos
/
Vacunas Virales
/
Vacunas Sintéticas
/
Virus de la Fiebre Aftosa
/
Anticuerpos Neutralizantes
/
Serogrupo
/
Fiebre Aftosa
/
Anticuerpos Antivirales
/
Epítopos
Límite:
Animals
Idioma:
En
Revista:
Virology
Año:
2024
Tipo del documento:
Article