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Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape.
Singh, Param Priya; Reeves, G Adam; Contrepois, Kévin; Papsdorf, Katharina; Miklas, Jason W; Ellenberger, Mathew; Hu, Chi-Kuo; Snyder, Michael P; Brunet, Anne.
Afiliación
  • Singh PP; Department of Genetics, Stanford University, Stanford, CA, USA. Electronic address: param.singh@ucsf.edu.
  • Reeves GA; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Contrepois K; Department of Genetics, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Papsdorf K; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Miklas JW; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Ellenberger M; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Hu CK; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Snyder MP; Department of Genetics, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
  • Brunet A; Department of Genetics, Stanford University, Stanford, CA, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, San Francisco, CA, USA. Electronic address: a
Cell ; 187(13): 3338-3356.e30, 2024 Jun 20.
Article en En | MEDLINE | ID: mdl-38810644
ABSTRACT
Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diapausa Límite: Animals Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diapausa Límite: Animals Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article