Your browser doesn't support javascript.
loading
Decreased spermatogonial numbers in boys with severe haematological diseases.
Lahtinen, Atte K; Funke, Miriam; Krallmann, Claudia; Wyrwoll, Margot J; Jarisch, Andrea; Yang, Yifan; Bjarnason, Ragnar; Romerius, Patrik; Sundin, Mikael; Norén-Nyström, Ulrika; Langenskiöld, Cecilia; Cremers, Jann-Frederik; Kliesch, Sabine; Stukenborg, Jan-Bernd; Neuhaus, Nina; Jahnukainen, Kirsi.
Afiliación
  • Lahtinen AK; Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Funke M; Department of Medical and Clinical Genetics/Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Krallmann C; Centre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University Münster, Munster, Germany.
  • Wyrwoll MJ; Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany.
  • Jarisch A; Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany.
  • Yang Y; Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescent Medicine, University Hospital Frankfurt, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
  • Bjarnason R; NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
  • Romerius P; Children's Medical Center, Landspítali University Hospital, Reykjavik, Iceland.
  • Sundin M; Department of Paediatrics, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Norén-Nyström U; Department of Paediatric Oncology and Haematology, Clinical Sciences, Lund University, Barn-Och Ungdomssjukhuset Lund, Skånes Universitetssjukhus, Lund, Sweden.
  • Langenskiöld C; Division of Paediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Cremers JF; Section of Paediatric Haematology, Immunology and HCT, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
  • Kliesch S; Division of Paediatrics, Department of Clinical Science, Umeå University, Umeå, Sweden.
  • Stukenborg JB; Department of Paediatric Oncology, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
  • Neuhaus N; Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany.
  • Jahnukainen K; Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Munster, Germany.
Br J Haematol ; 205(1): 229-235, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38810989
ABSTRACT
This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espermatogonias / Trasplante de Células Madre Hematopoyéticas / Enfermedades Hematológicas Límite: Adolescent / Child / Child, preschool / Humans / Infant / Male Idioma: En Revista: Br J Haematol Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espermatogonias / Trasplante de Células Madre Hematopoyéticas / Enfermedades Hematológicas Límite: Adolescent / Child / Child, preschool / Humans / Infant / Male Idioma: En Revista: Br J Haematol Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido