Nuclear SMAD5 dances to a different tune in regulating insulin secretion.
Cell Metab
; 36(6): 1169-1171, 2024 Jun 04.
Article
en En
| MEDLINE
| ID: mdl-38838638
ABSTRACT
In this issue of Cell Metabolism, Fang et al.1 report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic ß cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Células Secretoras de Insulina
/
Proteína Smad5
/
Secreción de Insulina
/
Insulina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Metab
Asunto de la revista:
METABOLISMO
Año:
2024
Tipo del documento:
Article