Local complement activation and modulation in mucosal immunity.
Mucosal Immunol
; 17(4): 739-751, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38838816
ABSTRACT
The complement system is an evolutionarily conserved arm of innate immunity, which forms one of the first lines of host response to pathogens and assists in the clearance of debris. A deficiency in key activators/amplifiers of the cascade results in recurrent infection, whereas a deficiency in regulating the cascade predisposes to accelerated organ failure, as observed in colitis and transplant rejection. Given that there are over 60 proteins in this system, it has become an attractive target for immunotherapeutics, many of which are United States Food and Drug Administration-approved or in multiple phase 2/3 clinical trials. Moreover, there have been key advances in the last few years in the understanding of how the complement system operates locally in tissues, independent of its activities in circulation. In this review, we will put into perspective the abovementioned discoveries to optimally modulate the spatiotemporal nature of complement activation and regulation at mucosal surfaces.
Palabras clave
ATG7; C3 F/S; C3 fast/slow; CCAAT; CXCL; DSS; FXR; HSV-1; ICAM; IRF; JAK1/2; Janus kinase ½; MAPK; MMP; NLRP3; PPAR; PTEN; RELA - v-rel; ROS; STAT1; VEGF-A; autophagy related 7; chemokine (C-X-C motif) ligand; cytosine-cytosine-adenosine-adenosine-thymidine; dextran sodium sulfate; farnesoid X receptor; herpes simplex virus-1; intercellular adhesion molecule; interferon regulatory factor; matrix metalloproteinase; mitogen-activated protein kinase; nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3; peroxisome proliferator-activated receptor; phosphatase and tensin homolog; reactive oxygen species; reticuloendotheliosis viral oncogene homolog A (avian); signal transducer and activation of transcription 1; vascular endothelial growth factor-A
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas del Sistema Complemento
/
Activación de Complemento
/
Inmunidad Mucosa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mucosal Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos