Autophagy mediated targeting degradation, a promising strategy in drug development.
Bioorg Chem
; 149: 107466, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38843684
ABSTRACT
Targeted protein degradation (TPD) technologies have become promising therapeutic approaches through degrading disease-causing proteins via the protein degradation system. Autophagy is a fundamental biological process with a high relationship to protein degradation, which belongs to one of two main protein degradation pathways, the autophagy-lysosomal system. Recently, various autophagy-based TPD techniques ATTECs, AUTACs, and AUTOTACs, etc, have also been gradually developed, and they have achieved efficient degradation potency for the targeted protein, expanding the potential of degradation for large-size proteins or protein aggregates. Herein, we introduce the machinery of autophagy and its relation to protein degradation, and multiple methods for using autophagy to specifically degrade target proteins.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Proteolisis
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Desarrollo de Medicamentos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Bioorg Chem
Año:
2024
Tipo del documento:
Article