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Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia.
Liu, Yanyan; Qi, Qi; Jiang, Yaqin; Zhao, Peiran; Chen, Lijie; Ma, Xiaqing; Shi, Yuhan; Xu, Jianxun; Li, Jinjin; Chen, Feixiang; Chen, Jian; Zhang, Le; Wu, Yelin; Jiang, Xingwu; Jin, Dayong; Xu, Tao; Bu, Wenbo.
Afiliación
  • Liu Y; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Qi Q; Department of Anesthesiology, Shanghai Sixth Peoples Hospital Affiliated to Shanghai Jiao tong University, Shanghai, 200233, China.
  • Jiang Y; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Zhao P; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
  • Chen L; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Ma X; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Shi Y; Department of Anesthesiology, Shanghai Sixth Peoples Hospital Affiliated to Shanghai Jiao tong University, Shanghai, 200233, China.
  • Xu J; Baylor College of medicine, Houston, TX 77030, USA.
  • Li J; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Chen F; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
  • Chen J; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Zhang L; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Wu Y; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, New South Wales, 2007, Australia.
  • Jiang X; Department of Medical Ultrasound, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, 200072, China.
  • Jin D; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China.
  • Xu T; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, New South Wales, 2007, Australia.
  • Bu W; Department of Anesthesiology, Shanghai Sixth Peoples Hospital Affiliated to Shanghai Jiao tong University, Shanghai, 200233, China.
Angew Chem Int Ed Engl ; 63(34): e202405131, 2024 Aug 19.
Article en En | MEDLINE | ID: mdl-38845566
ABSTRACT
The limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB2, comprising hexagonal boron sheets alternating with Mg2+. In pathological environment, Mg2+ is exchanged by H+, forming two-dimensional borophene-analogue BH sheets. BH interacts with the charged cations via cation-pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg2+ competes Ca2+ to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal -35.9 mV to -5.9 mV after the addition of MgB2, indicating potent analgesic effect. In three typical pain models, including CFA-induced inflammatory pain, CINP- or CCI-induced neuropathic pain, MgB2 exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO4, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non-opioid medical need for pain relief.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Magnesio Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Magnesio Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: China