Two cases of misleading Epstein-Barr virus infection and the role of EBV-DNA.
IDCases
; 36: e02001, 2024.
Article
en En
| MEDLINE
| ID: mdl-38846027
ABSTRACT
Two atypical cases of infectious mononucleosis in two teenagers with initially negative serology and non-evocative blood examinations are reported. The first patient had recently traveled to Africa, and Epstein-Barr virus negative serology led us to make many extensive investigations. The second patient complained of asthenia for a month, and PET/CT was performed to suspicion of lymphoma. PET scan revealed hypermetabolic lymph nodes in the supradiaphragmatic and subdiaphragmatic stations, along with18F-FDG uptake in the spleen and pharynx, raising more suspicion of lymphoma. Fortunately, Epstein-Barr virus DNA testing was performed and turned positive in both cases, and Epstein-Barr virus serology subsequently became positive. Diagnosing EBV infection can be challenging in rare cases, as EBV-specific serology may be negative in the early stages and confounding factors may be present. Therefore, Epstein-Barr virus DNA testing should be considered early in the diagnostic algorithm to prevent unnecessary investigations in similar cases.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
IDCases
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia