Your browser doesn't support javascript.
loading
Comprehensive transcriptome profiling between balding and non-balding scalp of female pattern hair loss in Asian.
Kim, Soon Re; Kim, Yun Ji; Kim, Ju-Hee; Kim, Su Na; Park, Won Serk; Kim, Se Hwan; Chung, Juhyun; Choi, Mi Soo; Kim, MyungHwa; Park, Byung Cheol.
Afiliación
  • Kim SR; Basic and Clinical Hair institute, Dankook University, Cheonan, Republic of Korea.
  • Kim YJ; Beckman Laser Institute Korea, DanKook University, Cheonan, Republic of Korea.
  • Kim JH; Theragen Bio Institute, Seongnam, Republic of Korea.
  • Kim SN; Basic and Clinical Hair institute, Dankook University, Cheonan, Republic of Korea.
  • Park WS; AmorePacific R&D Center, Yongin, Republic of Korea.
  • Kim SH; AmorePacific R&D Center, Yongin, Republic of Korea.
  • Chung J; Beckman Laser Institute Korea, DanKook University, Cheonan, Republic of Korea.
  • Choi MS; Department of Biomedical Engineering, School of Medicine, Dankook University, Cheonan, Republic of Korea.
  • Kim M; Department of Dermatology, Dankook University Hospital, Cheonan, Republic of Korea.
  • Park BC; Department of Dermatology, Dankook University Hospital, Cheonan, Republic of Korea.
Arch Dermatol Res ; 316(7): 360, 2024 Jun 08.
Article en En | MEDLINE | ID: mdl-38850442
ABSTRACT
While many gene expression studies have focused on male pattern baldness (MPB), few studies have investigated the genetic differences between bald and non-bald hair follicles in female pattern hair loss (FPHL). This study aimed to identify molecular biomarkers associated with FPHL through genetic analysis of paired bald and non-bald hair follicles from 18 FPHL patients, using next-generation sequencing (NGS) techniques. RNA transcriptome analysis was performed to identify differentially expressed genes (DEGs) between bald and non-bald hair follicles in FPHL. The DEGs were validated using real-time PCR, and protein expression was confirmed through immunohistochemistry and western blot analysis. Our findings suggest that HOXB13, SFRP2, PTGDS, CXCR3, SFRP4, SOD3, and DCN are significantly upregulated in bald hair follicles compared to non-bald hair follicles in FPHL. SFRP2 and PTGDS were found to be consistently highly expressed in bald hair follicles in all 18 samples. Additionally, elevated protein levels of SFRP2 and PTGDS were confirmed through western blot and immunohistochemical analysis. Our study identified SFRP2 and PTGDS as potential biomarkers for FPHL and suggests that they may play a role in inducing hair loss in this condition. These findings provide a foundation for further research on the pathogenesis of FPHL and potential therapeutic targets.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Folículo Piloso / Perfilación de la Expresión Génica / Pueblo Asiatico / Alopecia Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arch Dermatol Res / Arch. dermatol. res / Archives of dermatological research Año: 2024 Tipo del documento: Article Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Folículo Piloso / Perfilación de la Expresión Génica / Pueblo Asiatico / Alopecia Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arch Dermatol Res / Arch. dermatol. res / Archives of dermatological research Año: 2024 Tipo del documento: Article Pais de publicación: Alemania