A novel function of the M<sub>2</sub> muscarinic receptor.

Wess, Jürgen; Liu, Liu

A novel function of the M₂ muscarinic receptor.

Wess, Jürgen; Liu, Liu.

Afiliación

Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, 8 Center Drive MSC 0810, Bethesda, MD 20892, USA. Electronic address: jurgenw@niddk.nih.gov.
Liu L; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, 8 Center Drive MSC 0810, Bethesda, MD 20892, USA.

Trends Pharmacol Sci ; 45(8): 663-665, 2024 Aug.

Article en En | MEDLINE | ID: mdl-38853101

ABSTRACT

ABSTRACT

The M2 muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M2 receptor mRNA, directing the expression of a C-terminal receptor fragment. Elevated during cellular stress, this polypeptide localizes to mitochondria where it inhibits oxidative phosphorylation.

Asunto(s)

Receptor Muscarínico M2; Humanos; Receptor Muscarínico M2/metabolismo; Receptor Muscarínico M2/genética; Animales; Mitocondrias/metabolismo; Fosforilación Oxidativa

Palabras clave

G protein-coupled receptor; internal ribosome entry site; knock-in mouse; mitochondria; oxidative phosphorylation; receptor fragment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor Muscarínico M2 Límite: Animals / Humans Idioma: En Revista: Trends Pharmacol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

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