Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.
Philos Trans R Soc Lond B Biol Sci
; 379(1906): 20230240, 2024 Jul 29.
Article
en En
| MEDLINE
| ID: mdl-38853555
ABSTRACT
Synaptic plasticity is a key cellular model for learning, memory and chronic pain. Most previous studies were carried out in rats and mice, and less is known about synaptic plasticity in non-human primates. In the present study, we used integrative experimental approaches to study long-term potentiation (LTP) in the anterior cingulate cortex (ACC) of adult tree shrews. We found that glutamate is the major excitatory transmitter and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionicacid (AMPA) receptors mediate postsynaptic responses. LTP in tree shrews was greater than that in adult mice and lasted for at least 5 h. N-methyl-d-aspartic acid (NMDA) receptors, Ca2+ influx and adenylyl cyclase 1 (AC1) contributed to tree shrew LTP. Our results suggest that LTP is a major form of synaptic plasticity in the ACC of primate-like animals. This article is part of a discussion meeting issue 'Long-term potentiation 50 years on'.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tupaiidae
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Receptores de N-Metil-D-Aspartato
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Receptores AMPA
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Potenciación a Largo Plazo
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Giro del Cíngulo
Límite:
Animals
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido