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Synthesis and stability of the [45Ti]Ti-DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals.
Roy, Tamal; Pogorilyy, Eduard; Kumarananthan, Chubina P; Kvitastein, Unni A; Foscato, Marco; Törnroos, Karl W; Adamsen, Tom C H; Le Roux, Erwan.
Afiliación
  • Roy T; Department of Chemistry, University of Bergen, Allégaten 41, Bergen, Norway. Erwan.LeRoux@uib.no.
  • Pogorilyy E; Department of Chemistry, University of Bergen, Allégaten 41, Bergen, Norway. Erwan.LeRoux@uib.no.
  • Kumarananthan CP; Department of Radiology, Haukeland University Hospital, Centre for Nuclear Medicine and PET, Jonas Lies vei 65, Bergen, Norway.
  • Kvitastein UA; Department of Radiology, Haukeland University Hospital, Centre for Nuclear Medicine and PET, Jonas Lies vei 65, Bergen, Norway.
  • Foscato M; Department of Chemistry, University of Bergen, Allégaten 41, Bergen, Norway. Erwan.LeRoux@uib.no.
  • Törnroos KW; Department of Chemistry, University of Bergen, Allégaten 41, Bergen, Norway. Erwan.LeRoux@uib.no.
  • Adamsen TCH; Department of Chemistry, University of Bergen, Allégaten 41, Bergen, Norway. Erwan.LeRoux@uib.no.
  • Le Roux E; Department of Radiology, Haukeland University Hospital, Centre for Nuclear Medicine and PET, Jonas Lies vei 65, Bergen, Norway.
Chem Commun (Camb) ; 60(56): 7148-7151, 2024 Jul 09.
Article en En | MEDLINE | ID: mdl-38860653
ABSTRACT
We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with 45Ti, via a guaiacol-based liquid-liquid extraction method, leads to a high radiochemical conversion up to 98%.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Titanio / Radiofármacos / Compuestos Heterocíclicos con 1 Anillo Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Titanio / Radiofármacos / Compuestos Heterocíclicos con 1 Anillo Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido