The multifaceted role of SOX2 in breast and lung cancer dynamics.
Pathol Res Pract
; 260: 155386, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38861919
ABSTRACT
Breast and lung cancers are leading causes of death among patients, with their global mortality and morbidity rates increasing. Conventional treatments often prove inadequate due to resistance development. The alteration of molecular interactions may accelerate cancer progression and treatment resistance. SOX2, known for its abnormal expression in various human cancers, can either accelerate or impede cancer progression. This review focuses on examining the role of SOX2 in breast and lung cancer development. An imbalance in SOX2 expression can promote the growth and dissemination of these cancers. SOX2 can also block programmed cell death, affecting autophagy and other cell death mechanisms. It plays a significant role in cancer metastasis, mainly by regulating the epithelial-to-mesenchymal transition (EMT). Additionally, an imbalanced SOX2 expression can cause resistance to chemotherapy and radiation therapy in these cancers. Genetic and epigenetic factors may affect SOX2 levels. Pharmacologically targeting SOX2 could improve the effectiveness of breast and lung cancer treatments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Factores de Transcripción SOXB1
/
Neoplasias Pulmonares
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Pathol Res Pract
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Alemania