Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma.
Indian J Pathol Microbiol
; 2024 Jun 08.
Article
en En
| MEDLINE
| ID: mdl-38864442
ABSTRACT
CONTEXT Rspondin 1 (Rspo1), a protein family member featuring secreted furin-like domains, plays a pivotal role in cancer development and exhibits a positive correlation with tumor progression. However, its expression in esophageal squamous cell carcinoma (ESCC) is still unknown. AIMS:
Here, we assessed the correlation between Rspo1 and clinicopathological features of ESCC patients, and further investigated the potential role of Rspo1 in ESCC development and clinical outcomes. SETTINGS ANDDESIGN:
This was a pilot study. MATERIALS ANDMETHODS:
A total of 112 paraffin-embedded tumor samples from patients with ESCC, including 68 matched adjacent normal tissues, were collected post-surgery. Subsequently, tissue microarray (TMA) and immunohistochemistry (IHC) techniques were employed to assess the protein levels of Rspo1. STATISTICALANALYSIS:
All statistical analyses were performed with SPSS 20.0 (SPSS, Inc., Chicago, IL).RESULTS:
We found that Rspo1 expression was significantly higher in ESCC than in adjacent normal tissues (P < 0.0001). Moreover, Rspo1 was highly expressed in ESCC tumor specimens and showed a significant correlation with the T classification of ESCC (P < 0.05). Additionally, our findings indicate a positive relationship between Rspo1 and survival time in ESCC. Patients exhibiting moderate to high levels of Rspo1 expression demonstrated superior survival outcomes compared to those with low expression (P = 0.0002).CONCLUSIONS:
Our investigation has demonstrated that Rspo1 is upregulated in ESCC and exhibits a positive correlation with disease progression. Furthermore, we have observed a significant association between Rspo1 overexpression and improved patient survival rates, indicating its potential as a prognostic marker and therapeutic target for ESCC treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Indian J Pathol Microbiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
IN
/
INDIA
/
ÍNDIA